Antihypertensive effects of Brazilian propolis: identification of caffeoylquinic acids as constituents involved in the hypotension in spontaneously hypertensive rats.

@article{Mishima2005AntihypertensiveEO,
  title={Antihypertensive effects of Brazilian propolis: identification of caffeoylquinic acids as constituents involved in the hypotension in spontaneously hypertensive rats.},
  author={Satoshi Mishima and Chie Yoshida and Sayuko Akino and Takashi Sakamoto},
  journal={Biological & pharmaceutical bulletin},
  year={2005},
  volume={28 10},
  pages={1909-14}
}
Brazilian propolis was extracted with water or various concentrations of ethanol and were administered orally to spontaneously hypertensive rats (SHR) and the effects on blood pressure and heart rate were determined. Single oral administration of 100 mg/kg of propolis extracts decreased the blood pressure in SHR. Significant decrease in blood pressure was observed with propolis extracted with 25 and 70% ethanol. SHR were given orally 5 mg/kg of propolis extracted with 25 or 70% ethanol, twice a… CONTINUE READING
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