Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats.

@article{Karaki1990AntihypertensiveEO,
  title={Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats.},
  author={Hideaki Karaki and Kentaro Doi and Sumio Sugano and Hideyo Uchiwa and R Sugai and Ujihiro Murakami and Steve K Takemoto},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1990},
  volume={96 2},
  pages={367-71}
}
1. Repeated oral administrations of tryptic hydrolysate of bovine milk casein (CEI) showed antihypertensive effect in spontaneously hypertensive rats. 2. Single oral administration of CEI antagonized the pressor response to angiotensin I. 3. Bovine milk casein hydrolysate inhibited the angiotensin I-converting enzyme (ACE) activity. Three peptides with ACE-inhibiting activity were isolated from CEI. 4. It is suggested that ACE-inhibiting peptides in the tryptic hydrolysate milk casein are… CONTINUE READING
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