Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: A comparison with hydralazine

@article{Velasco1975AntihypertensiveEO,
  title={Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: A comparison with hydralazine},
  author={M. Velasco and Charles A. Gilbert and Charles O. Rutledge and John L. McNay},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1975},
  volume={18}
}
The cardiovascular effects of a new antihypertensive drug, bupicomide, were compared with those of hydralazine in 6 patients with mild to moderate hypertension. The mean supine arterial pressure of patients was reduced 15.2 mm Hg by bupicomide (900 to 2,000 mg/day) and 15.7 mm Hg by hydralaslne (300 to 600 mg/day). Heart rate increased an average of 11.3 bpm during bupicomide and 14.5 bpm by hydralaine. Neither drug was associated with a postural decrease in mean arterial pressure. The heart… 
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27 Citations

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Citation Type

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The heart rate response to hydralazine was dose-related and the dose-response curve was shifted to the right by clonidine, and the increase in mean blood pressure induced by the cold pressor test was significantly attenuated byClonidine.
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It is concluded that clonidine can be used as an alternative to β‐adrenergic blockers to counteract the increased sympathetic nervous activity minoxidil induces.
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TLDR
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New inhibitors of dopamine β-hydroxylase
Dopamine: a role in the pathogenesis and treatment of hypertension
  • M. Murphy
  • Medicine, Biology
    Journal of Human Hypertension
  • 2000
TLDR
Evidence is emerging that abnormalities in DA production, or in signal transduction of the D1 receptor in renal proximal tubules, may result in salt retention and high blood pressure in some humans and in several animal models of hypertension.
Clinical Pharmacokinetics of Hydralazine
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Since there is no clear-cut correlation between the plasma concentration of the drug and its effect upon blood pressure, there is at present no reason to routinely measure plasma levels of hydrallazine in treated hypertensive patients.
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