Antihypertensive drugs methyldopa, labetalol, hydralazine, and clonidine improve trophoblast interaction with endothelial cellular networks in vitro.

@article{Xu2014AntihypertensiveDM,
  title={Antihypertensive drugs methyldopa, labetalol, hydralazine, and clonidine improve trophoblast interaction with endothelial cellular networks in vitro.},
  author={Bei Xu and Francesca Charlton and Angela Makris and A Orlitsky Hennessy},
  journal={Journal of hypertension},
  year={2014},
  volume={32 5},
  pages={1075-83; discussion 1083}
}
OBJECTIVES The interaction between trophoblasts and maternal endothelium is important for placental vascular modeling. Failure of uterine spiral artery transformation is linked to the etiopathology of preeclampsia. Antihypertensive medications used to control hypertension in early pregnancy can alter placental and circulating cytokines. This study… CONTINUE READING