• DOI:10.1111/J.1527-3466.1999.TB00002.X
Corpus ID: 17532379

Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11.

@article{Chatelain1998AntihypertensiveAN,
  title={Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11.},
  author={R. Chatelain and R. Ghai and A. Trapani and L. Odorico and B. Dardik and S. De Lombaert and R. Lappe and C. Fink},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={284 3},
  pages={
          974-82
        }
}

• R. Chatelain, R. Ghai, +5 authors C. Fink
• Published 1998
• Chemistry, Medicine
• The Journal of pharmacology and experimental therapeutics

Dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitors, by decreasing angiotensin-II production and by preventing the degradation of atrial natriuretic peptide (ANP), may be useful for the treatment of hypertension and congestive heart failure. The thiol dipeptide CGS 30440 (prodrug of CGS 30008, IC50: ACE/NEP = 19/2 nM) administered to rats (10 mg/kg p.o.) inhibited lung tissue ACE activity by 98% and 61% at 1 and 24 hr (P < .001) and inhibited the angiotensin-I… Expand

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