Corpus ID: 20279799

Antihypertensive activity of a propranolol analog (ORF 12,592) in rodents.

  title={Antihypertensive activity of a propranolol analog (ORF 12,592) in rodents.},
  author={N Ram and R. D. Heilman and Forrest C. Greenslade},
  journal={Archives internationales de pharmacodynamie et de therapie},
  volume={224 1},
Studies were carried out to determine the antihypertensive effects of the 5-hydroxy derivative (ORF 12,592) of propranolol. Acute administration of ORF 12,592 produced a reduction in mean systolic blood pressure in desoxycorticosterone acetate (DOCA) rats and in spontaneously hypertensive rats (SHR). Propranolol was not effective in DOCA rats and produced a significant blood pressure reduction in SHR 48 hr after acute administration. These results demonstrated antihypertensive activity of an… Expand
3 Citations
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