• Corpus ID: 44048171

Antihypertensive activity of Hibiscus Sabdariffa aqueous calyx extract in Albino rats

  title={Antihypertensive activity of Hibiscus Sabdariffa aqueous calyx extract in Albino rats},
  author={G AbubakarM. and N UkwuaniA. and U MandeU.},
The anti-hypertensive activity of aqueous calyx extract of Hibiscus sabdariffa on salt induce hypertensive albino rats was investigated for 28 days using the non invasive method. The extract and drug treated groups showed a significant (P < 0.01) reduction in diastolic and systolic blood pressure when compared to the normotensive and hypertensive rats. There was no significant difference (P > 0.05) between the drug treated group and the extract treated group during this treatment. Thus, this… 

Tables from this paper

Anti-Hypertensive Effects of Anthocyanins from Hibiscus sabdarifa Calyx on the Renin-Angiotensin-Aldoslestrone System in Wistar Rats.

The results suggest that anthocyanins exerts a significant (p<0.05) anti-hypertensive potency on rats, probably mediated by the reduction in components of the RAAS.

Antihypertensive Effects of Aqueous Extract of Ricinodendron heudelotii (Baill.) Pierre (Euphorbiaceae) in Wistar Rat

Histological analysis showed that Ricinodendron heudelotii restored renal disorders induced by the administration of salt and exerts a cardioprotective effect, and the antihypertensive activity seems associated with an improvement in antioxidant status.

Hypotensive and vascular activities of medicinal plants

The aqueous extract of saffron stigma had hypotensive properties which appear to be attributable, in part, to the actions of two major constitutes of this plant, crocin andsafranal, and safranal was more important than crocin for lowering the blood pressure of rats.

Effect of Different Drying Methods on the Nutritional Value of Hibiscus sabdariffa Calyces as Revealed by NMR Metabolomics

NMR metabolomics indicates that the metabolite composition significantly differs between SD and TD samples and is more stable in TD plant processing, which shows that the TD method is more efficient at reducing moisture and maintaining the ash content of the Hibiscus biomass.

Optimization of an Extraction Solvent for Angiotensin-Converting Enzyme Inhibitors from Hibiscus sabdariffa L. Based on Its UPLC-MS/MS Metabolic Profiling

Interestingly, it was showed that the 80% methanol extract was predominated with secondary metabolites from all classes including flavonoids, anthocyanins, phenolic and organic acids, which indicates that these compounds may significantly contribute synergistically to the ACE inhibitory activity of the 80%, which exceeds that of the standard captopril.

Potential Protective Role of Vitamin E in Lung of Adult Male Albino Rat Exposed to Bisphenol A

Vitamin E protected lungs against BPA induced histopathological changes like inflammation, congestion, inter alveolar septum thickening,Alveolar damage, collagen fibers percent area and fatty infiltration, as depicted by significant decrease in the cluster of differentiation 68 (CD68) +ve cell count and decreased expression of nuclear factor kappa B in immunestained cells of the lung tissue.

Serum Adropin Levels in a Preeclampsia Like L-Name Rat Model Treated with Sildenafil Citrate

Increased maternal adropin levels in preeclampsia like model in rats might represent a regulatory feedback mechanism against endothelial placental dysfunction, insulin resistance, inflammation and oxidative stress which associated with preeclampedia, hence identify it as a potentially protective agent against preeclampia development.

Evaluation of Serum Obestatin Level in Rat Model of Diabetic Nephropathy

Serum OBST levels were significantly elevated in experimentally induced diabetic nephropathy in rats and positively correlated with most of the measured biochemical and renal parameters except for insulin, HDL-C and GFR was negatively correlated.

Ameliorative effect of apelin-13 against renal complications in L-NAME-induced preeclampsia in rats

In conclusion, apelin may be a potentially curative candidate for prohibiting kidney damage and have a therapeutic benefit in PE rat models.

Attenuation of salt-induced hypertension by aqueous calyx extract of Hibiscus sabdariffa.

It is suggested that HS attenuated the development of salt-induced hypertension and this attenuation may be associated with its high K+ content or high potassium: sodium ratio and not with altered pressor/depressor response to noradrenalin or acetylcholine.

Investigation of the antispasmodic potential of Hibiscus sabdariffa calyces.

Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats

The LD50 of roselle calyx extract and its effect on blood pressure were determined and a significant decrease in serum creatinine, cholesterol, and glucose in the treated rats compared with the control as well as a significant increase in serum uric acid was observed.

Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces.

[In vitro enzyme inhibitory and in vivo cardioprotective activities of hibiscus (Hibiscus sabdariffa L.)].

A crude hydroalcoholic extract from Hibiscus sabdariffa L. calyces showed in vitro an appreciable enzyme-inhibiting activity towards the Angiotensin I Converting Enzyme (ACE), attributable to

An evaluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians: a double blind, placebo controlled trial

At a dose of 1 gm/day, hibiscus sabdariffa leaf extract did not appear to have a blood lipid lowering effect and it is likely that the observed effects were as a result of the patients following the standard dietary and physical activity advice.


In the present investigation it was found that phenols, alkaloids, tannins, flavanoids, Saponin are present in leaves, stem and root of the plant.

Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne.

Results indicate that naturally occurring agents such as the bioactive compounds in H. sabdariffa could be developed as potent chemopreventive agents and natural healthy foods.

Diuretic activity of plants used for the treatment of urinary ailments in Guatemala.

Mechanism of Relaxant Effect Mediated by an Aqueous Extract of Hibiscus sabdariffa Petals in Isolated Rat Aorta

The results of this study suggest that HS relaxes vascular smooth muscle via a mechanism that is associated with an inhibition of Ca2+ influx through receptor operated channels and also on inhibition ofCa2+ release from intracellular stores.