Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension

@article{Saruta2007AntihypertensiveEA,
  title={Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension},
  author={Takao Saruta and Toshio Ogihara and Hiroaki Matsuoka and Hiromichi Suzuki and Megumi Toki and Yukio Hirayama and Kenji Nonaka and Kihito Takahashi},
  journal={Hypertension Research},
  year={2007},
  volume={30},
  pages={729-739}
}
A randomized, double-blind, placebo-controlled, parallel-group multicenter study was conducted to evaluate the antihypertensive efficacy and safety of 8-week treatment with one of three fixed-dose combinations—losartan 50 mg plus hydrochlorothiazide 12.5 mg, losartan 50 mg plus hydrochlorothiazide 6.25 mg, or losartan 25 mg plus hydrochlorothiazide 6.25 mg—in comparison with those of hydrochlorothiazide 12.5 mg alone, losartan 50 mg alone, or placebo in Japanese patients with essential… CONTINUE READING
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