Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats

  title={Antihypertensive Effect of an Extract of Passiflora edulis Rind in Spontaneously Hypertensive Rats},
  author={Toshiaki Ichimura and Akiko Yamanaka and Toshio Ichiba and Tetsuya Toyokawa and Yasuhiro Kamada and Takako Tamamura and Susumu Maruyama},
  journal={Bioscience, Biotechnology, and Biochemistry},
  pages={718 - 721}
Orally administered methanol extract of Passiflora edulis rind (10 mg/kg or 50 mg/kg) or luteolin (50 mg/kg), which is one of consistent polyphenols of the extract, significantly lowered systolic blood pressure in spontaneously hypertensive rats (SHRs). Quantitative analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) showed that the extract contained 20 μg/g dry weight of luteolin and 41 μg/g dry weight of luteolin-6-C-glucoside. It also contained γ-aminobutyric acid (GABA, 2… Expand
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