Antihypertensive Activity of SCH 31846, a Non‐Sulfhydryl Angiotensin‐Converting Enzyme Inhibitor

  title={Antihypertensive Activity of SCH 31846, a Non‐Sulfhydryl Angiotensin‐Converting Enzyme Inhibitor},
  author={T. Baum and E. Sybertz and R. W. Watkins and H. S. Ahn and S. Nelson and Emma Eynon and G. V. Vliet and Kathryn K. Pula and Crawford Sabin and D. Desiderio and F. Becker and S. Vemulapalli},
  journal={Journal of Cardiovascular Pharmacology},
  • T. Baum, E. Sybertz, +9 authors S. Vemulapalli
  • Published 1983
  • Medicine
  • Journal of Cardiovascular Pharmacology
  • Summary The antihypertensive, hemodynamic, and autonomic actions of SCH 31846, a new, potent and long-acting non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor, were evaluated in several experimental preparations. Oral administration of 0.3–3 mg/kg caused dose-related decreases in blood pressure in spontaneously hypertensive rats (SHRs). Pretreatment with a diuretic augmented the maximum hypotensive response attainable. Single doses (3 mg/kg) of SCH 31846 reduced pressure for over 24… CONTINUE READING
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