Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models.

  title={Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models.},
  author={Atul Goel and Nidhi Agarwal and Fateh Veer Singh and Ashoke Sharon and P. Tiwari and Manish Dixit and Ramendra Pratap and Arvind K. Srivastava and Prakas Ranjan Maulik and Vishnu Ji Ram},
  journal={Bioorganic & medicinal chemistry letters},
  volume={14 5},
Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model. 

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