• Corpus ID: 32433743

Antihyperglycemic Effect of Chicory Leaves and Vanadium Consumption on Diabetic Experimental Rats

@inproceedings{Sh2012AntihyperglycemicEO,
  title={Antihyperglycemic Effect of Chicory Leaves and Vanadium Consumption on Diabetic Experimental Rats},
  author={Waffa Sh},
  year={2012}
}

• Waffa Sh
• Published 2012
• Biology

This study was carried out to investigate the effect of cichorium leaves and vanadium consumption on diabetic rats. Forty two Sprague Dawley adult male rats were injected with a single intraperitoneal dose of streptozotocin to induce diabetes then classified into control positive group (C+) and five treated groups which were Amaryl drug group (AD), cichorium powder group (CP), cichorium extract group (CE), cichorium powder with vanadium group (CPV) and cichorium extract with vanadium group (CEV). All the treated groups showed significant increase in weight gain and feed efficiency ratio and the more improvement in nutritional results appeared in CEV. Values of insulin, hemoglobin, glutathione-peroxidase, superoxide dismutase and catalase in serum and glycogen in liver were significantly increased in all treated groups compared with C+ group. Values of serum alanine and aspartate aminotransferase enzymes (ALT and AST), glucose and glucosalated heamoglobin were significantly decreased in all treated groups. Also, values of cholesterol, triglyceride, low density lipoprotein cholesterol and nitric oxide in serum, cholesterol and total lipid in liver and atherogenic index were significantly decreased in all treated groups compared with C+ group. Serum alkaline phosphatase and creatinine were significantly decreased but high density lipoprotein cholesterol was significantly increased in CP, CE, CPV and CEV groups but serum urea was insignificantly difference compared with C+ group. This study recommended that the intake of cichorium extract with vanadium may be useful for treating diabetes.