Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats

  title={Antihyperglycemic, Antioxidant and Antiglycation Activities of Mulberry Leaf Extract in Streptozotocin-Induced Chronic Diabetic Rats},
  author={Jarinyaporn Naowaboot and Patchareewan Pannangpetch and Veerapol Kukongviriyapan and Bunkerd Kongyingyoes and Upa Kukongviriyapan},
  journal={Plant Foods for Human Nutrition},
In Thailand, beverages containing mulberry leaf (Morus alba L.) are believed to promote good health, especially in people with diabetes. We examined the effects of long-term administration of an ethanolic extract of mulberry leaf (MA) on blood glucose, oxidative damage, and glycation in streptozotocin-induced diabetic rats. Daily administration of 1 g/kg MA for six weeks decreased blood glucose by 22%, which was comparable to the effect of 4 U/kg insulin. Lipid peroxidation, measured as… 

Cytoprotective activity of mulberry leaf extract against oxidative stress-induced cellular injury in rats.

Results indicate that the MA leaf extract possesses the cytoprotective activity against free radical-induced cell injury, and may potentially be used as a food supplement in patients with certain diseases in which the oxidative stress-induced cellular injury is pathologically involved.

Protective effect of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats

It is demonstrated that mulberry flavonoids may improve the recovery of a severe peripheral nerve injury in alloxan-induced diabetic rats and is likely to be useful as a potential treatment on peripheral neuropathy (PN) in diabetic rats.

Mulberry Leaf Extract Attenuates Oxidative Stress-Mediated Testosterone Depletion in Streptozotocin-Induced Diabetic Rats

The findings indicated that MAE significantly increased Ts production in the diabetic rats, probably through the induction of StAR mRNA expression levels.

Antihyperglycemic activity of agarwood leaf extracts in STZ-induced diabetic rats and glucose uptake enhancement activity in rat adipocytes

It is suggested that agarwood leaf is a promising potential antidiabetic agent.

Morus nigra leaf extract improves glycemic response and redox profile in the liver of diabetic rats.

It is demonstrated that treatment of diabetic rats with leaf extracts decreased the superoxide dismutase (SOD)/catalase (CAT) ratio and carbonylated protein levels by reducing oxidative stress, suggesting the utility of this herbal remedy in the prevention and treatment of DM.

Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats

B. crassifolia can be considered as a potential safe anti-diabetic agent that can improve hyperlipidemia and hyperinsulinemia in streptozotocin-induced diabetic rats and exhibited significant inhibitory activity against AGEs.

Antihyperglycemic of Gleditschiae Spina Extracts in Streptozotocin-Nicotinamide Induced Type 2 Diabetic Rats

GSE could ameliorate type 2 diabetes and be comparable to acarbose, a standard hypoglycemic drug, and it is suggested that GSE may possess antioxidant activity against the STZ-NA-induced oxidative stress.

Comparative Regulatory Effects of Morus Alba Leaf Extracts on HepaticEnzymes in Streptozotocin-Induced Diabetic and Non-Diabetic Rats

It could possibility be suggested that the anti-hyperglycemic effect of MAE is mediated at least partially by increasing liver GPX and GR activity as well as decrease serum levels of liver enzymes ALT, AST and ALP.

Attenuation of nonenzymatic glycation, hyperglycemia, and hyperlipidemia in streptozotocin-induced diabetic rats by chloroform leaf extract of Azadirachta indica

Azadirachta indica can improve hyperlipidemia and hyperinsulinema in streptozocin-induced diabetic rats and, therefore, AI can be potentially considered to be an antidiabetic-safe agent.



Inhibitory effects of Luobuma tea and its components against glucose-mediated protein damage.

  • T. YokozawaT. Nakagawa
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2004

Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba.

Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether, which showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.62 micro, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.

The Influence of Maca (Lepidium meyenii) on Antioxidant Status, Lipid and Glucose Metabolism in Rat

Results demonstrate that maca seems to be promising for a positive influence on chronic human diseases (characterized by atherogenous lipoprotein profile, aggravated antioxidative status, and impaired glucose tolerance), and their prevention.

Polyphenol-Rich Extract of Fenugreek Seeds Protect Erythrocytes from Oxidative Damage

Findings demonstrate the potent antioxidant properties of the fenugreek seed extract, which significantly reduced the oxidative modifications in both the groups.

The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS‐1 cells

The results suggest that medicinal plants of Islamabad and the Murree region of Pakistan may be potential natural resources for antidiabetic compounds.

Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2.

Screening methods to measure antioxidant activity of sorghum (sorghum bicolor) and sorghum products.

The ABTS and DPPH methods were demonstrated to have similar predictive power as ORAC on sorghum antioxidant activity and there is a need to standardize these methods to allow for data comparisons across laboratories.

Advanced glycation endproducts--role in pathology of diabetic complications.

  • N. Ahmed
  • Biology, Medicine
    Diabetes research and clinical practice
  • 2005