Antihyperalgesic effects of spinal cannabinoids.

  title={Antihyperalgesic effects of spinal cannabinoids.},
  author={Jenny D Richardson and Lin Aanonsen and Kenneth M Hargreaves},
  journal={European journal of pharmacology},
  volume={345 2},
Cannabinoids have been widely reported to produce antinociception in models such as tail flick and hot plate. However, their role in modulating thermal hyperalgesia is unknown. The potency of some drugs, such as the opioids, increases during hyperalgesia. Thus, we evaluated whether there is a change in the effectiveness of intrathecal cannabinoids with hyperalgesia. Additionally, we evaluated whether cannabinoids could inhibit capsaicin-evoked neurosecretion from isolated rat spinal cord. Our… CONTINUE READING
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