Antihyperalgesic and antiallodynic effect of sirolimus in rat model of adjuvant arthritis.


Sirolimus is an immunosupressive drug that specifically inhibit the activation of T-lymphocytes. This study was undertaken to investigate whether treatment with sirolimus exert analgesic effect in rat adjuvant-induced arthritis, an animal model of rheumatoid arthritis. Arthritis was induced by a single subcutaneous injection of Freund's complete adjuvant to… (More)
DOI: 10.1016/j.ejphar.2013.02.013


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