Antihyperalgesic and allodynic effect of granisetron-A P1 receptor agonist in vincristine induced neuropathy in mice

Abstract

Objective: Granisetron, GRA an adenosine receptor agonist with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that Granisetron inhibits hyperalgesia and allodynia in a new mice model of neuropathy induced by Vincristine, and exerts its effect preferentially… (More)

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