Antihyperalgesic Activity of the Methanol Extract and Some Constituents Obtained From Polygala cyparissias (Polygalaceae)

@article{KleinJnior2012AntihyperalgesicAO,
  title={Antihyperalgesic Activity of the Methanol Extract and Some Constituents Obtained From Polygala cyparissias (Polygalaceae)},
  author={L. Klein-J{\'u}nior and N. A. Meira and T. B. Bresolin and V. Cechinel-Filho and N. L. Quint{\~a}o},
  journal={Basic \& Clinical Pharmacology \& Toxicology},
  year={2012},
  volume={111}
}
Polygala cyparissias, used in folk medicine as an anaesthetic, has already demonstrated antinociceptive activity against acute pain. In this study, we investigated the antihyperalgesic activity of the P. cyparissias methanol extract (PCME) from which the following compounds were isolated: α‐spinasterol (PC1), 1,3‐dihydroxy‐7‐methoxyxanthone (PC2), 1,7‐dihydroxy‐2,3‐methylenedioxyxanthone (PC3) and 1,3,6,8‐tetrahydroxy‐2,7‐dimethoxyxanthone (PC4). The antihyperalgesic effect was evaluated using… Expand
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