Antihistone and anti-double-stranded deoxyribonucleic acid antibodies are associated with renal disease in systemic lupus erythematosus.

@article{CortsHernndez2004AntihistoneAA,
  title={Antihistone and anti-double-stranded deoxyribonucleic acid antibodies are associated with renal disease in systemic lupus erythematosus.},
  author={Josefina Cort{\'e}s-Hern{\'a}ndez and Josep Ordi-Ros and Mois{\'e}s Labrador and Segundo Buj{\'a}n and Eva Balada and Alfons Segarra and Miquel Vilardell-Tarr{\'e}s},
  journal={The American journal of medicine},
  year={2004},
  volume={116 3},
  pages={165-73}
}
PURPOSE We sought to assess the nephritogenic antibody profile of patients with systemic lupus erythematosus (SLE), and to determine which antibodies were most useful in identifying patients at risk of nephritis. METHODS We studied 199 patients with SLE, 78 of whom had lupus nephritis. We assayed serum samples for antibodies against chromatin components (double-stranded deoxyribonucleic acid [dsDNA], nucleosome, and histone), C1q, basement membrane components (laminin, fibronectin, and type… CONTINUE READING

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