Antihistamines: do they work? Further well‐controlled trials involving larger samples are needed

@article{Fumagalli2004AntihistaminesDT,
  title={Antihistamines: do they work? Further well‐controlled trials involving larger samples are needed},
  author={Federica Fumagalli and Ilaria Baiardini and Mercedes Pasquali and Enrico Compalati and Laura Guerra and Pierangela Massacane and Giorgio Walter Canonica},
  journal={Allergy},
  year={2004},
  volume={59}
}
Histamine is one of the most important steps in the phlogistic allergic reaction. Its activity is due to the link to specific receptors on the cellular surface. H1‐receptors of second generation are the most currently prescribed drugs in allergic diseases for their high selectivity, little or no central sedative effect, rapid onset of action and long half lives. Antihistamines can modulate part of immunological mechanisms involved in the pathogenesis of allergic inflammation reducing mediator… Expand
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