Antihistaminergic pretreatment prevents tissue extravasation of albumin from intra-abdominal trauma in rats.

Intra-abdominal surgery causes a loss of plasma into tissues within and around the abdomen, endangering tissue viability. Mast cells, containing histamine, are abundant in the abdominal cavity. In a model of mechanical intra-abdominal trauma, we investigated whether pretreatment with histaminergic H1 and H2 receptor blockers counteracts this extravasation… CONTINUE READING