Antihepatotoxic activity of Trichosanthes cucumerina
- S. S. Kumar, K. B. Raui, M. S. Krishna
This study was conducted to evaluate the anti-hepatotoxic effect of intraperitoneal administration of ethanol extract of Ficus vogeli (600mg/kg) in CCl4-induced hepatotoxicity in male albino rats. Phytochemically, the leaf extract contains tannin, alkaloid, flavonoid, carbohydrates, protein, saponin, steroids, terpenoids, fats and oil. The administration of the Ficus vogelii extract was at one phase of the experiment according to the body weight of the test animals. The ethanol extracts of Ficus vogelii significantly reduced (p<0.05) the level of activity of the hepatic enzyme markers in the serum (Alanine amino transferase (ALT), Aspartate amino transferase (AST), alkaline phosphate (ALP) and total bilirubin) which occurred due to induced oxidative stress. Relative to the control group, treatment with CCl4 significantly raised the levels of ALT, ASP, AST and total bilirubin in the serum. The animals that received Ficus vogelii showed not only reduced hepatocellular degeneration but also of hepatocellular regeneration when compared to the liver of those exposed to CCl4 alone. Thus the histopathological studies also supported the anti-hepatpotoxic action of the ethanol extract of Ficus vogelii. The results of this study clearly indicate that Ficus vogelii ethanol extract has a potent anti-hepatotoxicity action against carbon tetrachloride induced liver damage in rats. [EGBUNA, P. A. C.; JOSHUA, Parker Elijah and CHIGBO, Maureen Ujunwa. Antihepatotoxic Effects Of Ficus Vogelii Ethanol Leaf Extract On The Liver Function Indices Of Ccl4 –Induced Hepatotoxicity In Rats. Journal of American Science 2011;7(6):158-163]. (ISSN: 1545-1003). http://www.americanscience.org.