Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro.

@article{Lee2011AntihepatomaAO,
  title={Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro.},
  author={Yoon‐Mi Lee and Ji Hong Lim and Haejin Yoon and Young Nam Chun and Jong-Wan Park},
  journal={Hepatology},
  year={2011},
  volume={53 1},
  pages={
          171-80
        }
}
UNLABELLED Chaetocin, an antibiotic produced by Chaetomium species fungi, was recently found to have antimyeloma activity. Here we examined whether chaetocin has anticancer activities against solid tumors. Chaetocin inhibited the growth of mouse and human hepatoma grafts in nude mice. Immunohistochemical analyses revealed that chaetocin inhibits hypoxia-inducible factor-1α (HIF-1α) expression and vessel formation in the tumors. Chaetocin also showed antiangiogenic anticancer activities in HIF-1… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

  • P van Uden, NS Kenneth, S. Rocha
  • Biochem J ;412:477-484
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…