• Corpus ID: 30276048

Antihelminthic drugs as a treatment for hyperproliferative diseases

  title={Antihelminthic drugs as a treatment for hyperproliferative diseases},
  author={Alan R. Liss},
1These drugs can be combined with conventional chemotherapeutics such as cisplatin, carboplatin, adriamycin, taxol etc. and enhance tumor cell killing. 2Cytotoxic effects: binding to the microtubule system and disrupting its functions 3Induction of Nuclear Accumulation of p53 : Both FZ and MZ showed an apoptotic effect on the H460 cells 4Increased Half-Life of p53 in Drug-Treated Cells 5Selective Induction of Apoptosis by Fenbendazole and Mebendazole in Tumor Cells Carrying Wild-Type p53 6BZ… 

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