Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern

@article{Wiedemann2005AntiglucocorticoidTD,
  title={Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern},
  author={K. Wiedemann and C. Lauer and A. Loycke and T. Pollm{\"a}cher and P. Durst and J. Macher and F. Holsboer},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2005},
  volume={241},
  pages={372-375}
}
  • K. Wiedemann, C. Lauer, +4 authors F. Holsboer
  • Published 2005
  • Psychology, Medicine
  • European Archives of Psychiatry and Clinical Neuroscience
  • SummaryMifepriston (RU 486) is a steroid antagonist which binds with high affinity to glucocorticoid receptors (GR), and also to progesterone receptors. The antiglucocorticoid action of Mifepriston in man has been demonstrated by blockade of the negative feedback action of endogenous cortisol and by antagonism of the effects of exogenously aministered dexamethasone. In the present study Mifepriston was administered to a normal male volunteer at 14.00 h and its effects on pituitary-adrenal… CONTINUE READING
    Neurochemical regulation of sleep.
    • 198
    Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression
    • 187
    • Open Access
    Reply: Clinical and Biological Effects of Mifepristone Treatment for Psychotic Treatment
    • 6
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 16 REFERENCES
    Gluco- and antimineralocorticoid effects on human sleep: a role of central corticosteroid receptors.
    • 144
    • Open Access