Antiglomerular Basement Membrane Antibody-Mediated Glomerulonephritis after Intranasal Cocaine Use

@article{Peces1999AntiglomerularBM,
  title={Antiglomerular Basement Membrane Antibody-Mediated Glomerulonephritis after Intranasal Cocaine Use},
  author={R. Peces and R. Navascu{\'e}s and J. Baltar and M. Seco and J. Alvarez},
  journal={Nephron},
  year={1999},
  volume={81},
  pages={434 - 438}
}
We report a case of rapidly progressive glomerulonephritis due to antiglomerular basement membrane (anti-GBM) antibodies that progressed to end-stage renal disease in a 35-year-old man who used intranasal cocaine on an occasional basis. In contrast to many prior reports of acute renal failure occurring with cocaine-associated rhabdomyolysis, this patient did not have any evidence of acute muscle damage and myoglobin release. Circulating anti-GBM antibodies and renal biopsy with linear IgG and… Expand
Sequential development of pulmonary hemorrhage with MPO-ANCA complicating anti-glomerular basement membrane antibody-mediated glomerulonephritis.
TLDR
Intensive combined immunosuppressive therapy with methylprednisolone bolus, oral prednisone, and cyclophosphamide led to negativity of anti-GBM antibodies but was not able to restore renal function. Expand
Antiglomerular Basement Membrane Disease
&NA; Antiglomerular basement membrane (anti‐GBM) disease is a rare but life‐threatening autoimmune vasculitis that is characterized by the development of pathogenic autoantibodies to type IV collagenExpand
An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy
TLDR
The need for careful interpretation of anti-GBM antibody tests in HIV infected patients with kidney disease and, in particular, the need for biopsy confirmation of the diagnosis prior to starting therapy is highlighted. Expand
Anti-glomerular basement membrane antibody disease: a case report and a review of Japanese patients with and without alveolar hemorrhage
TLDR
49 cases of anti-GBM antibody disease in patients with alveolar hemorrhage and patients without it reported in Japan from 1975 to 1999 are reviewed, examining the differences between these groups, and the characteristics of these rare diseases in Japan are clarified. Expand
Hepatitis B-related polyarteritis nodosa complicated by pulmonary hemorrhage.
TLDR
The cause of pulmonary hemorrhage in this case of polyarteritis nodosa is unclear, but may include underlying capillaritis, cocaine-induced pulmonary hemorrhages, or recurrent attacks of malignant hypertension. Expand
Goodpasture's Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association
TLDR
The case of a 40-year-old welder with silicosiderosis, who developed anti-GBM disease with p-ANCA positivity reinforces the role of environmental triggers like exposure to silica, metal dust, and tobacco in pathogenesis of Goodpasture's syndrome and p- ANCA associated vasculitis. Expand
Pemphigus Vegetans Associated with Intranasal Cocaine Abuse
TLDR
It is postulate that intranasal cocaine abuse is operative in a 42-year-old white male with a 12-month history of hypertrophic, vegetative plaques affecting primarily his external nares and upper lips who had a history of alcoholism and intermittent drug abuse. Expand
Acute bilateral renal infarction secondary to cocaine-induced vasospasm.
TLDR
Owing to the absence of a clear explanation for the patient's acute renal failure, renal biopsy was performed 12 days after the onset of symptoms. Expand
Characteristics and Outcomes of Patients With Goodpasture's Syndrome
TLDR
Patients with either pulmonary or renal signs and symptoms should be evaluated for Goodpasture's syndrome, since early diagnosis allows prompt treatment and improved outcome. Expand
Chronic nephropathies of cocaine and heroin abuse: a critical review.
TLDR
It is concluded although there is a paucity of evidence to support a heroin-associated nephropathy, the evidence from in vitro cellular and animal studies to support the existence of cocaine-induced renal changes is more convincing. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 47 REFERENCES
Antiglomerular basement membrane glomerulonephritis following D-penicillamine-associated nephrotic syndrome.
Antiglomerular basement membrane (anti-GBM) glomerulonephritis (GN) is rare and is characterized by rapidly progressive GN with IgG linear deposits along the GBM in immunofluorescence study andExpand
Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease.
TLDR
The patient reported here had the unusual combination of c-ANCA antibodies with anti-GBM disease, and this association raises complex questions regarding the pathogenesis of this type of renal injury. Expand
Pulmonary hemorrhage and antiglomerular basement membrane antibody‐mediated glomerulonephritis after exposure to smoked cocaine (crack): A case report and review of the literature
TLDR
A case of Goodpasture's syndrome with a negative immunofluorescence examination of the lung biopsy in a 32‐year‐old man who had been smoking cocaine (crack) up to 3 weeks before hospital admission, which Illustrates the potentially complex Interrelations between an autoimmune disease and exposure to substances with possible antigenic properties. Expand
Goodpasture Syndrome: Molecular and Clinical Advances
TLDR
Goodpasture syndrome is a rare but important autoimmune disorder characterized by pulmonary hemorrhage and glomerulonephritis, and intriguing observations suggest that cigarette smoking, infection, or chemicals expose the antigen, leading to antibody production in genetically susceptible individuals. Expand
Severe rhabdomyolysis with renal failure after intranasal cocaine use.
TLDR
A case of acute renal failure due to rhabdomyolysis in a patient who used cocaine on a daily basis and recovered fully after 3 weeks of dialysis is presented. Expand
Pathogenic significance of interleukin-6 in a patient with antiglomerular basement membrane antibody-induced glomerulonephritis with multinucleated giant cells.
  • Y. Ito, A. Fukatsu, +4 authors S. Matsuo
  • Medicine
  • American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1995
TLDR
Serum IL-6, anti-glomerular basement membrane antibody, and acute-phase proteins were markedly elevated, and returned dramatically to the normal level after corticosteroid therapy and plasmapheresis, suggesting that IL- 6 played an important role in the development of many symptoms in the present case. Expand
Goodpasture's syndrome in a patient receiving penicillamine and carbimazole.
TLDR
A 51-year-old woman with advanced rheumatoid arthritis developed a Goodpasture's syndrome during treatment with penicillamine and carbimazole, and responded dramatically to pulse methylprednisolone and cyclophosphamide, with both clinical remission and disappearance of anti-GBM antibodies. Expand
Leukocyte involvement in the pathogenesis of pulmonary injury in experimental Goodpasture's syndrome.
TLDR
The feasibility of using passive accelerated anti-GBM disease as a model of Goodpasture's syndrome is demonstrated, and it is suggested that inflammatory macrophages are the major cellular participants in progressive pulmonary injury after antibody deposition. Expand
Course and prognosis of anti-basement membrane antibody (anti-BM-Ab)-mediated disease: report of 35 cases.
TLDR
The earlier therapy starts, the better the result, and patients presenting early with a serum creatinine < 200 mumol/l and without severe glomerular alterations gained the most benefit from therapy, indicating that outcome may be improved by early diagnosis. Expand
Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome.
TLDR
The correlation of alpha 1-alpha 6(IV) NC1 reactivity in a large number of patients with anti-GBM antibodies defined by classic assays definitively establishes that reactivity to alpha 3(IV] NC1 domains is both sufficient and necessary for the expression of autoimmune disease directed to the NC1 domain of Type IV collagen. Expand
...
1
2
3
4
5
...