Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor.

Abstract

Malignant gliomas are highly dependent on the isoprenoid pathway for the synthesis of lipid moieties critical for cell proliferation. The isoprenoid derivative N6-isopentenyladenosine (iPA) displays pleiotropic biological effects, including a direct anti-tumor activity in several tumor models. The antiglioma effects of iPA was then explored in U87MG cells… (More)
DOI: 10.1002/ijc.30505

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Cite this paper

@article{Ciaglia2017AntigliomaEO, title={Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor.}, author={Elena Ciaglia and Mario Abate and Chiara Laezza and Simona Pisanti and Mario Vitale and Vincenzo Seneca and Giovanni Torelli and Silvia Franceschelli and Giuseppe Catapano and Patrizia Gazzerro and Maurizio Bifulco}, journal={International journal of cancer}, year={2017}, volume={140 4}, pages={959-972} }