Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo.

@article{Jortzik2014AntigliomaAO,
  title={Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo.},
  author={Esther Jortzik and Mohammad Reza Farhadi and Rezvan Ahmadi and Katalin Toth and Jennifer Lohr and Burkhard Maria Helmke and Sebastian Kehr and Andreas Unterberg and Ingo Ott and Ronald Gust and Val{\'e}rie Deborde and Elisabeth Davioud-Charvet and R{\'e}gis R{\'e}au and Katja Becker and Christel C. Herold-Mende},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1844 8},
  pages={1415-26}
}
Glioblastoma, an aggressive brain tumor, has a poor prognosis and a high risk of recurrence. An improved chemotherapeutic approach is required to complement radiation therapy. Gold(I) complexes bearing phosphole ligands are promising agents in the treatment of cancer and disturb the redox balance and proliferation of cancer cells by inhibiting disulfide… CONTINUE READING