Antigiardial activity of isoflavones from Dalbergia frutescens bark.

@article{Khan2000AntigiardialAO,
  title={Antigiardial activity of isoflavones from Dalbergia frutescens bark.},
  author={Ikhlas Ahmad Khan and Mitchell A. Avery and Charles L. Burandt and Deneva Goins and Julie Rakel Mikell and Theodore Elliott Nash and Ali Azadegan and Larry A Walker},
  journal={Journal of natural products},
  year={2000},
  volume={63 10},
  pages={1414-6}
}
Several isoflavones [formononetin (1), castanin (5), odoratin (6), glycitein (7), pseudobaptogenin (8), fujikinetin (9), and cuneatin (10)] were isolated from Dalbergia frutescens, and their antiprotozoal activities were determined against Giardia intestinalis. Among these compounds, formononetin (1) was the most potent antigiardial agent, with an IC(50) value of 30 ng/mL (approximately 0.1 microM), as compared to the value for metronidazole, the current drug of choice, of 100 ng/mL… CONTINUE READING

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