Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides

@article{GutirrezGutirrez2017AntigiardialAO,
  title={Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides},
  author={Filiberto Guti{\'e}rrez-Guti{\'e}rrez and Ana Mar{\'i}a Puebla-P{\'e}rez and Sirenia Gonz{\'a}lez-Pozos and J Manuel Hern{\'a}ndez-Hern{\'a}ndez and Armando P{\'e}rez-Rangel and Laura Alvarez and Gabriela Tapia-Pastrana and Araceli Castillo-Romero},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2017},
  volume={22}
}
Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides, namely, 5′-desmethoxy… 

Figures and Tables from this paper

Lignans from Bursera fagaroides: Chemistry, Pharmacological Effects and Molecular Mechanism. A Current Review
TLDR
This review covers literature-reported lignans from B. fagaroides, chemical structures, nomenclature, chromatographic techniques of isolation, characterization strategies, and highlights the anti-cancer molecular mechanisms of lignan metabolites.
Identification and molecular characterization of the tubulin‐podophyllotoxin‐type lignans binding site on Giardia lamblia
TLDR
It is demonstrated that 5′‐desmethoxy‐peltatin‐A‐methylether (5‐DES), acetylpodophyllotoxin (APOD), and podophyllOToxin (POD) affect the distribution and staining pattern of microtubular structures on Giardia trophozoites.
Polyphenolic extract from Punica granatum peel causes cytoskeleton-related damage on Giardia lamblia trophozoites in vitro
TLDR
The in vitro antigiardial potential of polyphenolic extract from pomegranate peel was evaluated and it was found that the extract alters α-tubulin expression and distribution in Giardia trophozoites in a concentration-independent manner.
An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.
The genus Bursera belongs to the family Burseraceae and has been used in traditional Mexican medicine for treating various pathophysiological disorders. The most representative phytochemicals
Lignans from Bursera fagaroides Affect In Vivo Cell Behavior by Disturbing the Tubulin Cytoskeleton in Zebrafish Embryos
TLDR
The zebrafish model can be a fast and cheap in vivo model that can be used to identify antimitotic natural products through bioassay-guided fractionation and demonstrate that the cytotoxic activity of 1, 2, and 4 is mediated by their microtubule-destabilizing activity.
Effects of Decavanadate Salts with Organic and Inorganic Cations on Escherichia coli, Giardia intestinalis, and Vero Cells.
TLDR
All three compounds were significantly less toxic to Vero cells than the reference drug employed in the treatment of giardiasis and open a path to the development of new therapeutic agents.
Chemistry and Biology of Selected Mexican Medicinal Plants.
TLDR
The chapter shows that there is need to conduct additional clinical studies on herbal drugs, in particular because the longstanding traditional evidence for their safety is not always sufficient to assure their rational use.
On the nature of organic electron density transfer complexes within molecular electron density theory.
TLDR
Analysis of the Parr functions of the separated reagents and the topological analysis of the electron density of the EDTCs allow the understanding of the subtle changes in the electronic structure of this significant class of molecular complexes, and consequently, their physical properties.

References

SHOWING 1-10 OF 43 REFERENCES
In vitro activity of the F-6 fraction of oregano against Giardia intestinalis
TLDR
It is demonstrated that a 2-h treatment with 2·87 μg ml−1 of fraction 6 of Lippia graveolens (F-6) was sufficient to kill half of an experimental Giardia intestinalis population, based on the reduction of MTT-tetrazolium salt levels.
Antigiardial activity of novel triazolyl-quinolone-based chalcone derivatives: when oxygen makes the difference
TLDR
45 novel chalcone derivatives with triazolyl-quinolone scaffold represent potential candidates for the design of novel antigiardial drugs, being highly selective against Giardia trophozoites, and underlines the importance of taking O2 into account when testing novel potential antigardial compounds.
Cytotoxic and Anti-inflammatory Activities of Bursera species from Mexico
TLDR
Organic extracts from nine species of the Bursera genus native to Mexico were investigated for cytotoxic and anti-inflammatory activities and demonstrated that the studied species possess pharmacological potential qualities for developing plant medicines.
Cytotoxic Podophyllotoxin Type-Lignans from the Steam Bark of Bursera fagaroides var. fagaroides
The hydroalcoholic extract of the steam bark of B. fagaroides var. fagaroides displayed potent cytotoxic activity against four cancer cell lines, namely KB (ED50 = 9.6 × 10−2 μg/mL), PC-3 (ED50 = 2.5
Terminalia ferdinandiana extracts as inhibitors of Giardia duodenalis proliferation: a new treatment for giardiasis
TLDR
The low toxicity of the Terminalia ferdinandiana fruit extracts and their potent G. duodenalis growth inhibitory bioactivity indicate their potential as medicinal agents in the treatment and prevention of this disease.
THE ANTI-PARASITE EFFECT OF PODOPHYLLOTOXIN ON GIARDIA LAMBLIA
Giardia lamblia is an intestinal protozoan parasite causing diarrhea in humans and some other mammalians world-wide. Giardia infects about 2% of the adults and 6 to 8% of the children worldwide and
Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines
TLDR
Four previously isolated aryltetralin lignans were evaluated for cytotoxicity, clonogenicity, and selectivity against three BC cell lines as well as the non-tumorigenic mammary epithelial cell line MCF-10A, suggesting a greater similarity with podophyllotoxin structure.
Cytotoxic and antitumour activity from Bursera fagaroides ethanol extract in mice with L5178Y lymphoma
TLDR
The cytotoxic and antitumour activity of the ethanol extract of the bark of B. fagaroides is determined and a significant increase in the survival of the treated animals was found compared with those treated with placebo or without treatment.
Aryldihydronaphthalene-type lignans from Bursera fagaroides var. fagaroides and their antimitotic mechanism of action
TLDR
This is the first report on the occurrence of aryldihydronaphthalene lignans in the genus Bursera of the Burseraceae family, as well as on the determination of their cytotoxic activity and mechanism of action.
...
...