Antigens in penicillin allergy. III. Antigen and antibody levels in mice treated with pure and contaminated penicillins.


Using a radioimmunoassay, it was shown that commercially available ampicillin preparations often contain penicilloylated high molecular weight impurities. These possess immunological activities and stimulate penicilloyl-specific antibody formation in mice treated according to a therapeutic schedule. Using purified and experimentally contaminated… (More)


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