Antigenotoxic effects of resveratrol: assessment of in vitro and in vivo response.

  title={Antigenotoxic effects of resveratrol: assessment of in vitro and in vivo response.},
  author={Suresh K. Abraham and Nidhi Khandelwal and Henning Hintzsche and Helga Stopper},
  volume={31 1},
Experiments were performed to evaluate the in vitro and in vivo dose response for antigenotoxic effects of resveratrol (RES). For the in vitro study, HL-60 cells were co-treated with the test genotoxin and three concentrations of RES. Thereafter, genotoxic effects were assessed in the cytokinesis-block micronucleus test. Results of the in vitro experiments using genotoxins nitroquinoline-1-oxide (NQO) and mitomycin C (MMC) showed maximum inhibition of genotoxicity with the lowest test… Expand
Vitamin E protects against cisplatin-induced genotoxicity in human lymphocytes.
Vitamin E can prevent the genotoxicity of cisplatin on cultured human lymphocyte, and is concluded to be a strong lipophilic antioxidant that has the ability to protect normal cells from chromosome damage and promote the repair of the damaged DNA. Expand
Efficacy of crocin and safranal as protective agents against genotoxic stress induced by gamma radiation, urethane and procarbazine in mice
Histopathological studies revealed that these saffron constituents reduced testicular cell damage induced by the test genotoxins, and co-administration of CRO with the nitrosation reaction mixture led to significant decrease in genotoxicity when compared to nitrosations reaction mixture alone. Expand
Antiproliferative and toxicogenomic effects of resveratrol in bladder cancer cells with different TP53 status
Resveratrol has antiproliferative activity in bladder tumor cells; however, the mechanisms of action are dependent on TP53 status. Expand
Pre and post treatment with curcumin and resveratrol protects astrocytes after oxidative stress
Cur and Res both protected astrocytes from oxidative stress by studying their potential to protect H2O2 induced oxidative stress at 4 h and 24’h time exposure and it was found that Cur is most effective in early hours of insult while Res is effective in late hours suggesting that Res may or may not have immediate effect on astroCytes. Expand
The Potential Use of Resveratrol for Cancer Prevention
To clarify if resveratrol has the potential for cancer prevention and the possibility of use in therapy, the following must be taken into account: data from epidemiology, clinical protocol, preclinical studies, and requirements of nanotechnologies in order to discover new drugs to fight cancer. Expand
Biphasic regulation of spindle assembly checkpoint by low and high concentrations of resveratrol leads to the opposite effect on chromosomal instability.
  • Xihan Guo, J. Ni, +4 authors Xu Wang
  • Biology, Medicine
  • Mutation research. Genetic toxicology and environmental mutagenesis
  • 2018
RSV exhibited a biphasic dose-dependent effect on CIN that was exerted via the regulation of mitotic fidelity through the SAC network, and the health implications of these findings were summarized. Expand
Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer
The role of the Mediterranean diet in the prevention of colorectal cancer and future perspectives are discussed in terms of food polyphenol content, the effectiveness, the plasma level, and the importance of other factors, such as thepolyphenol metabolites and the influence of the microbiome. Expand
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways
The mechanisms of action of these three important compounds on the cellular pathways involved with viral replication and the mechanisms of virus-related diseases, as well as the current status of their clinical use are outlined. Expand
Resveratrol attenuates bleomycin-induced genotoxicity, pulmonary fibrosis and DNA damage in balb/c mice with ehrlich ascites carcinoma
Bu çalışmanın amacı, resveratrolün (RES) Ehrlich asit karsinoması (EAT) taşıyan farelerde BLM’ye bağlı gelişen genotoksisite, akciğer fibrozisi ve DNA hasarı üzerindeki koruyucu etkisini araştırmaktır. Expand


Analysis of in vitro chemoprevention of genotoxic damage by phytochemicals, as single agents or as combinations.
The chemo-preventive effects of PEL, CLA, RES and EGCG against genotoxic damage induced by MMC, DEB and PAT are indicative of a 'saturation effect' when higher concentrations and combinations of these phytochemicals are used. Expand
Resveratrol mitigates genotoxicity induced by iodine-131 in primary human lymphocytes
Investigation of the radioprotective effects of resveratrol as a natural product that protects against genotoxic actions of 131I in cultured human lymphocytes indicates protective effects of Resver at low doses against genetic damage and adverse effects induced by 131I administration. Expand
Hormonal and genotoxic activity of resveratrol.
Determination of kinetochore signals in micronuclei and cell cycle analysis suggested that RES did not cause a direct disturbance of mitosis, and cell-free tubulin polymerization studies indicated no direct effect of RES on microtubule assembly. Expand
The genoprotective activity of resveratrol on aflatoxin B1-induced DNA damage in human lymphocytes in vitro
It is suggested for the first time that RSV can antagonize the ability of AFB1 to cause DNA damage that leads to the formation of SCEs and CAs, and the number of S CEs and micronuclei induced by AFB1 could be significantly minimized by the presence of RSV. Expand
Anti-genotoxicity of trans-anethole and eugenol in mice.
  • S. K. Abraham
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2001
Both trans-anethole and eugenol exerted dose-related antigenotoxic effects against PCB and URE and inhibited the genotoxicity of ethyl methane sulfonate (EMS). Expand
Safety studies conducted on high-purity trans-resveratrol in experimental animals.
In vitro and in vivo absorption, metabolism, and excretion studies in Caco-2 cells, rat primary hepatocytes and male and female rats show that Resvida is readily absorbed, metabolized and excreted, providing evidence that ResVida is well tolerated and non-toxic. Expand
In vivo anticlastogenic and antimutagenic effects of tannic acid in mice.
Results indicate that tannic acid acts as an anticlastogen and antimutagen in vivo. Expand
Dual role of resveratrol in modulation of genotoxicity induced by sodium arsenite via oxidative stress and apoptosis.
It is implicates that resveratrol is the most beneficial to cells at 1 and 5 μM and caution should be taken in applying resver atrol as an anticancer therapeutic agent or nutraceutical supplement due to its concentration dependent effect. Expand
Influence of resveratrol on oxidative damage in genomic DNA and apoptosis induced by cisplatin.
  • S. Attia
  • Biology, Medicine
  • Mutation research
  • 2012
Evidence for the first time is provided that resveratrol has a protective role in the abatement of cisplatin-induced genotoxicity and apoptosis in somatic and germinal cells of mice. Expand
Effect of resveratrol on chromosomal aberrations induced by doxorubicin in rat bone marrow cells.
Results indicate that RES (25mg/kgbw) significantly reduces frequency of DXR induced chromosome damage in bone marrow cells. Expand