Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride.

@article{Viswanadh2010AntigenotoxicEO,
  title={Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride.},
  author={E Kasi Viswanadh and Bhuvanagiri Nageshwar Rao and Bola Sadashiva Satish Rao},
  journal={Human & experimental toxicology},
  year={2010},
  volume={29 5},
  pages={
          409-18
        }
}
Cadmium is an environmental metal toxin implicated in human diseases. Mangiferin (MGN), a naturally occurring glucosylxanthone, is present in Mangifera indica. In this study, the protective role of MGN against cadmium chloride (CdCl(2))-induced genotoxicity was studied in Swiss albino mice. Mice were administered with single intra-peritoneal (i.p.) optimal dose of MGN (2.5 mg/kg b.wt.) before treatment with various concentrations of CdCl(2) (7, 8, 9, 10 and 11 mg/kg b.wt.). The LD( 50(30)) was… CONTINUE READING
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