Antigenicity and immunogenicity of P30-derived peptides in experimental models of toxoplasmosis.

@article{Godard1994AntigenicityAI,
  title={Antigenicity and immunogenicity of P30-derived peptides in experimental models of toxoplasmosis.},
  author={Ivan Godard and J{\'e}r{\^o}me Estaquier and Lionel Zenner and Marc Bossus and Claude Auriault and Françoise Darcy and H{\'e}l{\`e}ne Gras-Masse and Andr{\'e} Capron},
  journal={Molecular immunology},
  year={1994},
  volume={31 17},
  pages={1353-63}
}
P30, also referred to as SAG-1, is now recognized as a major Toxoplasma gondii antigen potentially important for both diagnosis and immunoprophylaxis of toxoplasmosis. By using predictive algorithms, five synthetic peptides (48-67, 82-102, 213-230, 238-256 and 279-285) derived from P30, were investigated for B- and T-cell determinants in mouse and rat experimental models. Antibody recognition appeared more broadly distributed along the P30 sequence, whereas T-cell recognition was mainly… CONTINUE READING