Antigenicity analysis of human parvovirus B19-VP1u protein in the induction of anti-phospholipid syndrome

@inproceedings{Lin2018AntigenicityAO,
  title={Antigenicity analysis of human parvovirus B19-VP1u protein in the induction of anti-phospholipid syndrome},
  author={Chun-Yu Lin and Chun-Ching Chiu and Ju Ming Cheng and Chia-yun Lin and Ya-Fang Shi and Chun-Chou Tsai and Bor-Show Tzang and Tsai-Ching Hsu},
  booktitle={Virulence},
  year={2018}
}
Mounting evidence suggests a connection between human parvovirus B19 (B19) and autoimmune diseases, and especially an association between the B19-VP1 unique region (VP1u) and anti-phospholipid syndrome (APS). However, little is known about the antigenicity of B19-VP1u in the induction of APS-like syndrome. To elucidate the antigenicity of B19-VP1u in the induction of APS, N-terminal truncated B19-VP1u (tVP1u) proteins were prepared to immunize Balb/c mice to generate antibodies against B19… CONTINUE READING

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