Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71

@article{Mao2011AntigenicityAP,
  title={Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71},
  author={Qunying Mao and Nan Li and Xiang Yu and Xin Yao and Fengxiang Li and Fengmin Lu and Hui Zhuang and Zheng-lun Liang and Jun-Zhi Wang},
  journal={Archives of Virology},
  year={2011},
  volume={157},
  pages={37-41}
}
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease. Recently, several EV71 inactivated vaccine candidates have been development in mainland China. To compare the antigenicity and genetic characteristics of different candidate vaccine strains for EV71, the genomes of 11 EV71 strains were sequenced. The cross-protection capacities were determined by neutralizing antibody test and were further assessed in neonatal mice. The results showed 93.0%–99.8% genome… CONTINUE READING

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