Antigenic variation of gonococcal pilin expression in vivo: analysis of the strain FA1090 pilin repertoire and identification of the pilS gene copies recombining with pilE during experimental human infection.

@article{Hamrick2001AntigenicVO,
  title={Antigenic variation of gonococcal pilin expression in vivo: analysis of the strain FA1090 pilin repertoire and identification of the pilS gene copies recombining with pilE during experimental human infection.},
  author={Terri S. Hamrick and Jack Alan Dempsey and Myron S. Cohen and Jonathan G. Cannon},
  journal={Microbiology},
  year={2001},
  volume={147 Pt 4},
  pages={839-49}
}
Antigenic variation of gonococcal pilin involves a family of variable genes that undergo homologous recombination, resulting in transfer of variant sequences from the pilS silent gene copies into the complete pilE expression locus. Little is known about the specific recombination events that are involved in assembling new variant pilin genes in vivo. One approach to understanding pilin variation in vivo is to carry out experimental human infections with a gonococcal strain having a fully… CONTINUE READING