Antigenic variation in Giardia lamblia is regulated by RNA interference

@article{Prucca2008AntigenicVI,
  title={Antigenic variation in Giardia lamblia is regulated by RNA interference},
  author={C{\'e}sar G. Prucca and Ileana Slavin and Rodrigo Quiroga and Eliana Vanina Elias and Fernando D. Rivero and Alicia Saura and Pedro G. Carranza and Hugo D Luj{\'a}n},
  journal={Nature},
  year={2008},
  volume={456},
  pages={750-754}
}
Giardia lamblia (also called Giardia intestinalis) is one of the most common intestinal parasites of humans. To evade the host’s immune response, Giardia undergoes antigenic variation—a process that allows the parasite to develop chronic and recurrent infections. From a repertoire of ∼190 variant-specific surface protein (VSP)-coding genes, Giardia expresses only one VSP on the surface of each parasite at a particular time, but spontaneously switches to a different VSP by unknown mechanisms… CONTINUE READING