Antigenic variation and resistance to neutralization in poliovirus type 1.

  title={Antigenic variation and resistance to neutralization in poliovirus type 1.},
  author={D C Diamond and B. A. Jameson and Jutta Bonin and Michinori Kohara and Shinobu Abe and Hirotaka Itoh and Takashi Komatsu and Minetaro Arita and Shusuke Kuge and A. Nomoto},
  volume={229 4718},
Mutations have been identified in variants of poliovirus, type 1 (Mahoney) on the basis of their resistance to neutralization by individual monoclonal antibodies. The phenotypes of these variants were defined in terms of antibody binding; the pattern of epitopes expressed or able to be exploited for neutralization were complex. Single amino acid changes can have distant (in terms of linear sequence) and generalized effects on the antigenic structure of poliovirus and similarly constituted… CONTINUE READING

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