Antigenic variants of the nonspecific cross-reacting antigen (NCA).

  title={Antigenic variants of the nonspecific cross-reacting antigen (NCA).},
  author={Pierre Burtin and G. Chavanel and Jean Claude Hendrick and N. Fr{\'e}noy},
  journal={Journal of immunology},
  volume={137 3},
Monoclonal antibodies (Mab) were prepared against nonspecific cross-reacting antigen (NCA) and were selected on the basis of their absence of reactivity with carcinoembryonic antigen (CEA). Four Mab were found which allowed the characterization on CEA of three epitopes, defined A, B, and C. These epitopes were all located on the peptidic moiety of this highly glycosylated antigen and were present on NCA molecules of heterogeneous m.w. (greater than 100,000, 80,000, and 48,000 m.w., the latter… CONTINUE READING