Antigenic variants of herpes simplex virus selected with glycoprotein-specific monoclonal antibodies.

@article{Holland1983AntigenicVO,
  title={Antigenic variants of herpes simplex virus selected with glycoprotein-specific monoclonal antibodies.},
  author={Thomas C. Holland and Steven D. Marlin and Michael Levine and Joseph Charles Glorioso},
  journal={Journal of virology},
  year={1983},
  volume={45 2},
  pages={672-82}
}
Monoclonal antibodies specific for herpes simplex virus type 1 (HSV-1) glycoproteins were used to demonstrate that HSV undergoes mutagen-induced and spontaneous antigenic variation. Hybridomas were produced by polyethylene glycol-mediated fusion of P3-X63-Ag8.653 myeloma cells with spleen cells from BALB/c mice infected with HSV-1 (strain KOS). Hybrid clones were screened for production of HSV-specific neutralizing antibody. The glycoprotein specificities of the antibodies were determined by… CONTINUE READING

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