Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination

Abstract

The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCC inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of… (More)
DOI: 10.1038/nm0498-421

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