Antigenic sites of coxsackievirus A9.

  title={Antigenic sites of coxsackievirus A9.},
  author={T Pulli and Hilkka Lankinen and Merja M Roivainen and Timo Hyypi{\"a}},
  volume={240 2},
Antigenic analysis of coxsackievirus A9 (CAV9) was carried out by using a peptide scanning method. Immunogenic regions in the capsid proteins VP1, VP2, and VP3 were recognized by antibodies in the sera of virus-immunized rabbits. The peptide sequences were scanned using a 12-amino-acid window and three-residue shift. Three immunogenic regions, located in the N- and C-terminal parts of VP1 and in the N-terminus of VP3, were identified. Trypsin treatment of the virus, known to cleave off the C… CONTINUE READING