Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus.

@article{Fleming1983AntigenicRO,
  title={Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus.},
  author={John O. Fleming and Stephen A. Stohlman and Richard C. Harmon and Michael M C Lai and Jeffrey A Frelinger and Leslie P. Weiner},
  journal={Virology},
  year={1983},
  volume={131 2},
  pages={296-307}
}
Monoclonal antibodies were produced to JHMV-DL, a neurotropic member of the mouse hepatitis virus (MHV) or murine coronavirus group. Of 23 antibodies isolated, 10 were specific for the major envelope glycoprotein, gp180/90, 10 for the nucleocapsid protein, pp60, and 3 for the minor envelope glycoprotein, gp25. Eleven different MHV isolates were used in antibody binding assays to study antigenic relationships among the viruses. Each MHV isolate tested had a unique pattern of antibody binding… CONTINUE READING

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