Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia

@article{Genovesi1977AntigenicMO,
  title={Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia},
  author={Eugene V Genovesi and Preston A Marx and E. Frederick Wheelock},
  journal={The Journal of Experimental Medicine},
  year={1977},
  volume={146},
  pages={520 - 534}
}
Friend leukemia virus (FLV) erythroleukemic cells cultured in medium containing FLV-immune serum from dormant FLV-infected mice undergo modulation of FLV cell surface antigens. Modulation was determined by an increased resistance to FLV antibody-mediated complement-dependent lysis and was associated temporally with the capping of FLV-immune complexes at the cell surface. Modulated cells regained their susceptibility to FLV antibody-mediated complement-dependent lysis when transferred to medium… CONTINUE READING
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