Antigenic heterogeneity of the guinea pig line 10 hepatocarcinoma. Implications for active specific immunotherapy

@article{Key2004AntigenicHO,
  title={Antigenic heterogeneity of the guinea pig line 10 hepatocarcinoma. Implications for active specific immunotherapy},
  author={Marc E. Key and Michael G. Hanna},
  journal={Cancer Immunology, Immunotherapy},
  year={2004},
  volume={12},
  pages={211-215}
}
Late metastatic disease was studied in L10 tumor-bearing guinea pigs which had shown an initial therapeutic response to a vaccine of x-irradiated L10 tumor cells plus BCG. A single metastatic lesion was isolated from two different animals showing evidence of tumor recurrence on days 134 and 212 after tumor implantation. These putative variants of the L10 parent were designated L10 variant 1 (L10-1) and L10 variant 2 (L10-2), respectively. Comparisons of the antigenic properties of the L10… CONTINUE READING