Antigenic drift in influenza A viruses. I. Selection and characterization of antigenic variants of A/PR/8/34 [HON1] influenza virus with monoclonal antibodies

@article{Gerhard1978AntigenicDI,
  title={Antigenic drift in influenza A viruses. I. Selection and characterization of antigenic variants of A/PR/8/34 [HON1] influenza virus with monoclonal antibodies},
  author={Walter Gerhard and R. G. Webster},
  journal={The Journal of Experimental Medicine},
  year={1978},
  volume={148},
  pages={383 - 392}
}
Antigenic variants of A/PR/8/34 [HON1] influenza virus were selected after a single passage of the parent virus in embryonated chicken eggs in the presence of monoclonal antibodies to this virus. The monoclonal antibodies were produced by a hybridoma and were specific for an antigenic determinant on the HA molecule of the parent virus. Seven antigenic variants were analyzed with 95 monoclonal anti-HA antibodies prepared in vitro in the splenic fragment culture system. Three subgroups of… CONTINUE READING
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The delineation of antigenic determinants of the hemagglutinin of influenza A viruses by means of moneclonal antibodies

  • W. Gerhard
  • In Topics in Infectious Diseases
  • 1978

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