Antigenic diversity thresholds and the development of AIDS.

  title={Antigenic diversity thresholds and the development of AIDS.},
  author={Martin A. Nowak and Roy M. Anderson and Angela R. McLean and Tom F. W. Wolfs and Jaap Goudsmit and Robert M. May},
  volume={254 5034},
Longitudinal studies of patients infected with HIV-1 reveal a long and variable incubation period between infection and the development of AIDS. Data from a small number of infected patients show temporal changes in the number of genetically distinct strains of the virus throughout the incubation period, with a slow but steady rise in diversity during the progression to disease. A mathematical model of the dynamic interaction between viral diversity and the human immune system suggests the… CONTINUE READING

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