Antigenic determinants of the chlamydial major outer membrane protein resolved at a single amino acid level.

@article{Zhong1991AntigenicDO,
  title={Antigenic determinants of the chlamydial major outer membrane protein resolved at a single amino acid level.},
  author={Guangming Zhong and Robert C. Brunham},
  journal={Infection and immunity},
  year={1991},
  volume={59 3},
  pages={1141-7}
}
Antigenic determinants were identified from seven chlamydial major outer membrane proteins by using overlapping hexapeptides and polyclonal antisera. Sixty-one determinants were detected, and 30 were surface exposed on the native organisms. The two negatively charged residues, aspartic acid and glutamic acid, were found most often in determinants. Thirteen antigenic sites were further characterized by alanine substitution. Differences in fine specificities of these linear determinants were… CONTINUE READING
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