Antigenic conservation of an immunodominant invariable region of the VlsE lipoprotein among European pathogenic genospecies of Borrelia burgdorferi SL.

@article{Liang2000AntigenicCO,
  title={Antigenic conservation of an immunodominant invariable region of the VlsE lipoprotein among European pathogenic genospecies of Borrelia burgdorferi SL.},
  author={Fang Liang and Elisabeth Aberer and Marina Cinco and L. E. Gern and Chang Min Hu and Yves Lobet and Maurizio Ruscio and Pierre Voet and Vincent E. Weynants and Mario T. Philipp},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={182 5},
  pages={1455-62}
}
Lyme disease is caused by genetically divergent spirochetes, including 3 pathogenic genospecies: Borrelia burgdorferi sensu stricto, B. garinii, and B. afzelii. Serodiagnosis is complicated by this genetic diversity. A synthetic peptide (C(6)), based on the 26-mer invariable region (IR(6)) of the variable surface antigen of B. burgdorferi (VlsE), was used as ELISA antigen, to test serum samples collected from mice experimentally infected with the 3 genospecies and from European patients with… CONTINUE READING

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