Antigenic and immunogenic properties of recombinant hepatitis A virus 14S and 70S subviral particles.

@article{Stapleton1993AntigenicAI,
  title={Antigenic and immunogenic properties of recombinant hepatitis A virus 14S and 70S subviral particles.},
  author={Jack T. Stapleton and Vinod Raina and Patricia L. Winokur and K Walters and Donna Klinzman and E U Rosen and J H McLinden},
  journal={Journal of virology},
  year={1993},
  volume={67 2},
  pages={1080-5}
}
Hepatitis A virus (HAV) has an immunodominant neutralization antigenic site. By using a panel of monoclonal antibodies targeted against the HAV neutralization antigenic site, it was shown that three epitopes within this site are present on 14S subunits (pentamers of the structural unit). In contrast, two other epitopes within this site are formed upon… CONTINUE READING